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"Dramatically reduced UV-dependent ubiquitylation was indeed observed in the stable Nedd4 knockdown cells compared to wild-type cells immediately after UV irradiation, but after 20 min, the level of ubiquitylation in the two cell lines was already similar, as expected (Figure 5D, compare lanes 5 and 6, and 7 and 8)." PMID:17996703

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type	Axiom
comment	"Dramatically reduced UV-dependent ubiquitylation was indeed observed in the stable Nedd4 knockdown cells compared to wild-type cells immediately after UV irradiation, but after 20 min, the level of ubiquitylation in the two cell lines was already similar, as expected (Figure 5D, compare lanes 5 and 6, and 7 and 8)." PMID:17996703 "Several independent experiments showed that UV-induced ubiquitylation was reproducibly affected only by Nedd4 siRNA (Figure 5C, compare lane 4 with lane 14 [control] and other knockdowns; data not shown). This indicates that Nedd4 is required for UV-induced ubiquitylation of RNAPII in vivo." PMID:17996703 "To investigate whether they could support human RNAPII ubiquitylation in vitro, highly purified human RNAPII was used as substrate, with human Uba1 and UbcH7 (or UbcH5C) involved as E1 and E2, respectively (Figure 6C, lanes 7–10). In this highly purified, reconstituted human RNAPII ubiquitylation system (see Figure S4 for purity of these proteins), Nedd4 (and Smurf1), but none of the other Rsp5 homologs, supported robust ubiquitylation of RNAPII (Figure 6C, lanes 2 and 3)." PMID:17996703
Date	2018-05-01
Contributor	http://orcid.org/0000-0002-1706-4196
annotatedProperty	http://purl.obolibrary.org/obo/RO_0002333
annotatedSource	http://model.geneontology.org/5323da1800000002/5323da180000003
annotatedTarget	http://purl.obolibrary.org/obo/#5323da1800000002%2F5595c4cb00000122
http://purl.org/pav/providedBy	http://www.wormbase.org
http://geneontology.org/lego/evidence	http://model.geneontology.org/5323da1800000002/5ae3b0f600000039 http://model.geneontology.org/5323da1800000002/5ae3b0f600000042

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