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  • Rule: ActivityStreamsMapasEquivalentb3sb3sifpccisofacetshttp://demo.openlinksw.com/dataspacehttp://www.w3.org/2002/07/owl#ldpoplwebrel-me-authskos-transsql-vdb-data-lakeurn:ALKAdatareducedurn:analytics:acqof:ruleurn:clothing:rule:qaurn:det:rdf:labelurn:inference:oplfaq:ruleurn:inference:product:feature:inverse:ruleurn:ingleng:inf:demo:inf:ruleurn:kbpedia:actor:subclass:test:rulesurn:kbpedia:comedian:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:mime-artist:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:philosopher:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:stage-actor:owl:equivalent:class:subproperty:inference:rulesurn:kgdemo:1:ifp:ruleurn:kgdemo:1:ifp:rule2urn:lava:demo:ruleurn:owl:equivalent:class:inference:rulesurn:rdfs:subclass:subproperty:inference:rulesurn:rdfs:type:wikidata:ruleurn:recon:data:ifpurn:recon:data:ifp:ruleurn:recruitment:rule:built-in:ruleurn:rsm12e:translation:ruleurn:rxnorm:data:ruleurn:se:demo:inference:ruleurn:test:skos:inverse:ruleurn:wireless:plans:features:builtin:inference:rule:1virtrdf-eturtle-containersvirtrdf-hashtagvirtrdf-ifpvirtrdf-labelvirtrdf-meta-entity-classvirtrdf-urlNone
    
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Rationale: The paper reports the cloning of the Na+/Ca2+ exchanger NCX3 and characterizes its transporter activity. Figure 6a reports an experiment where the NCX3 mRNA was injected in Xenopus oocytes (control- water injected). Na+ gradient-dependent labelled (45)Ca2+ uptake was measured under the following experimental conditions: -internal Na+ was elevated by incubation with nystatin. - the external solution contained labelled CaCl2 in a K+ medium, in the absence of external Na+. Figure 6b presents the results of a similar experiment but in BHK cells. The cells were transfected with the NCX3 DNA (control - non transfected cells). The specific Na+-dependent uptake of (45)Ca2+ is plotted. Under these conditions, the labeled Ca2+ uptake was larger than in the control. Background uptake levels were estimated by exchanging the external K+ ions for Na+, thereby eliminating the Na+ gradient which is necessary for Ca2+ uptake. Taken together, the experiment demonstrates that the identified cDNA codes for a Na+/Ca2+ exchanger.. Experimental description: A unique exchanger clone from a rat brain cDNA library was isolated. * 'Therefore, we subcloned a poly(A)1-containing fragment of DNA into the BglII-NotI site of pIII (Fig. 1). This replaced most of the original NCX3 39-UTR with the 39-UTR derived from the SGLT1 (Na1-glucose cotransporter) clone (Hediger et al., 1987)' as described previously (Li et al., 1994). The