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  • Rule: ActivityStreamsMapasEquivalentb3sb3sifpccisofacetshttp://demo.openlinksw.com/dataspacehttp://www.w3.org/2002/07/owl#ldpoplwebrel-me-authskos-transsql-vdb-data-lakeurn:ALKAdatareducedurn:analytics:acqof:ruleurn:clothing:rule:qaurn:det:rdf:labelurn:inference:oplfaq:ruleurn:inference:product:feature:inverse:ruleurn:ingleng:inf:demo:inf:ruleurn:kbpedia:actor:subclass:test:rulesurn:kbpedia:comedian:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:mime-artist:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:philosopher:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:stage-actor:owl:equivalent:class:subproperty:inference:rulesurn:kgdemo:1:ifp:ruleurn:kgdemo:1:ifp:rule2urn:lava:demo:ruleurn:owl:equivalent:class:inference:rulesurn:rdfs:subclass:subproperty:inference:rulesurn:rdfs:type:wikidata:ruleurn:recon:data:ifpurn:recon:data:ifp:ruleurn:recruitment:rule:built-in:ruleurn:rsm12e:translation:ruleurn:rxnorm:data:ruleurn:se:demo:inference:ruleurn:test:skos:inverse:ruleurn:wireless:plans:features:builtin:inference:rule:1virtrdf-eturtle-containersvirtrdf-hashtagvirtrdf-ifpvirtrdf-labelvirtrdf-meta-entity-classvirtrdf-urlNone
    
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Rationale: The paper reports the cloning of the Na+/Ca2+ exchanger (NCX1) from canine and characterizes its transporter activity. Figure 1 reports an experiment where the NCX1 mRNA was injected in Xenopus oocytes (control- water injected). Na+ gradient-dependent labelled (45)Ca2+ uptake was measured under the following experimental conditions: -internal Na+ was elevated by incubation with nystatin. - the external solution contained 10 uM of labelled CaCl2 in a K+ medium, in the absence of external Na+. Under these conditions, the labeled Ca2+ uptake was at least one order of magnitude greater than control or than previously observed in oocytes injected with poly(A)+ RNA from cardiac tissue (PMID: 2462361). When the external K+ ions were exchanged for Na+, or when the nystatin treatment was omitted, only background uptake levels were observed, indicating the need for a Na+ gradient for the Ca2+ uptake. Taken together, the experiment demonstrates that the identified cDNA codes for a Na+/Ca2+ exchanger.. Experimental description: Here we report the molecular cloning, expression, deduced amino acid sequence, and apparent molecular size of the canine cardiac sarcolemmal Na+-Ca2+ exchange protein.