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  • Rule: ActivityStreamsMapasEquivalentb3sb3sifpccisofacetshttp://demo.openlinksw.com/dataspacehttp://www.w3.org/2002/07/owl#ldpoplwebrel-me-authskos-transsql-vdb-data-lakeurn:ALKAdatareducedurn:analytics:acqof:ruleurn:clothing:rule:qaurn:det:rdf:labelurn:inference:oplfaq:ruleurn:inference:product:feature:inverse:ruleurn:ingleng:inf:demo:inf:ruleurn:kbpedia:actor:subclass:test:rulesurn:kbpedia:comedian:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:mime-artist:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:philosopher:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:stage-actor:owl:equivalent:class:subproperty:inference:rulesurn:kgdemo:1:ifp:ruleurn:kgdemo:1:ifp:rule2urn:lava:demo:ruleurn:owl:equivalent:class:inference:rulesurn:rdfs:subclass:subproperty:inference:rulesurn:rdfs:type:wikidata:ruleurn:recon:data:ifpurn:recon:data:ifp:ruleurn:recruitment:rule:built-in:ruleurn:rsm12e:translation:ruleurn:rxnorm:data:ruleurn:se:demo:inference:ruleurn:test:skos:inverse:ruleurn:wireless:plans:features:builtin:inference:rule:1virtrdf-eturtle-containersvirtrdf-hashtagvirtrdf-ifpvirtrdf-labelvirtrdf-meta-entity-classvirtrdf-urlNone
    
  • Inverse Functional Properties: Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects
  • "Same As": Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects (recommended) Apply to subjects, objects and predicates (not recommended on big datasets) Apply to predicates only (special use cases only)

Rationale: Fig. 3b, using pull-down experiment ADAM23 form a protein complex with LGl1, PSD-95 and and Kv1.2. Literal: "Major constituents of LGI1 complex contained ADAM23 as well as ADAM22 and PSD-95." Fig. 4b, ADAM23 coimmunoprecipitate with PSD-95 and Kv1.2. Literal: "Loss of LGI1 reduced the amount of both ADAM22 and ADAM23 in Triton X-100–insoluble crude synaptic fractions by ≈80% and inversely increased in Triton X- 100–soluble fractions (Fig. 5A). This is consistent with the data that the interaction of ADAM22 with postsynaptic PSD-95 is reduced in the LGI1−/− mouse" Fig. 5d, ADAM23 protein localizes in the outer molecular layers of the dentate gyrus Literal: "Our immunohistochemical analysis showed that ADAM23 protein localizes in the outer molecular layers of the dentate gyrus (Fig. 5D), where perforant path fibers from the entorhinal cortex terminate. These results suggest the presynaptic localization of ADAM23 at least in the molecular layer in the dentate gyrus. Given that the LGI1 protein complex contains both presynaptic and postsynaptic proteins (Fig. 3D), it is conceivable that LGI1 mediates the transsynaptic interaction between postsynaptic ADAM22 and presynaptic ADAM23." Fig. S3a ADAM23 is enriched in Triton X-100–soluble presynaptic and insoluble PSD fractions. Literal: "ADAM22, and ADAM23 were enriched both in Triton X-100–soluble presynaptic and insoluble postsynaptic density (PSD) fractions" 7/6/2017 Pim These data show that: (i) ADAM23 is found in dame molecular complex as PSD-95 (ii) That the interaction of ADAM23 and PSD-95 is direct (iii) ADAM23 is enriched in PSD fractions. Note: ADAM23 has a TM domain.. Experimental description: Biochemical and immunohistochemical experiments were done on mouse brain Literal from M&M "For immunoprecipitation of endogenous ADAM22 or ADAM23, one mouse brain was homogenized in buffer C" "Subcellular Fractionation. Brains from littermate mice (P16) were homogenized in buffer C." "Immunohistochemistry. Littermate mice (P17–19) were anesthetized by pentobarbital"