• Facets (new session)
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• Metadata
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  • Rule: ActivityStreamsMapasEquivalentb3sb3sifpccisofacetshttp://demo.openlinksw.com/dataspacehttp://www.w3.org/2002/07/owl#ldpoplwebrel-me-authskos-transsql-vdb-data-lakeurn:ALKAdatareducedurn:analytics:acqof:ruleurn:clothing:rule:qaurn:det:rdf:labelurn:inference:oplfaq:ruleurn:inference:product:feature:inverse:ruleurn:ingleng:inf:demo:inf:ruleurn:kbpedia:actor:subclass:test:rulesurn:kbpedia:comedian:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:mime-artist:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:philosopher:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:stage-actor:owl:equivalent:class:subproperty:inference:rulesurn:kgdemo:1:ifp:ruleurn:kgdemo:1:ifp:rule2urn:lava:demo:ruleurn:owl:equivalent:class:inference:rulesurn:rdfs:subclass:subproperty:inference:rulesurn:rdfs:type:wikidata:ruleurn:recon:data:ifpurn:recon:data:ifp:ruleurn:recruitment:rule:built-in:ruleurn:rsm12e:translation:ruleurn:rxnorm:data:ruleurn:se:demo:inference:ruleurn:test:skos:inverse:ruleurn:wireless:plans:features:builtin:inference:rule:1virtrdf-eturtle-containersvirtrdf-hashtagvirtrdf-ifpvirtrdf-labelvirtrdf-meta-entity-classvirtrdf-urlNone
    
  • Inverse Functional Properties: Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects
  • "Same As": Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects (recommended) Apply to subjects, objects and predicates (not recommended on big datasets) Apply to predicates only (special use cases only)

Rationale: Figure 1C,D: Depolarization of CA1 postsynaptic pyramidal neurons mobilizes endocannabinoids, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (depolarization-induced suppression of inhibition or DSI) or glutamatergic excitatory neurotransmission (depolarization-induced suppression of excitation or DSE). DSI is lost in CB1 knockout mice (Figure 1C,D). Additionally, DSE is lost in CB1 knockout mice (Figure 8A of Ohno-Shosaku, T. et al (2002) J Neurosci, 22(10), 3864-3872). Figure 3: In addition, evidence is shown that presynaptic N-Type Ca2+ channels are required for endocannabinoid signaling. DSI is occluded by a specific antagonist of N-type channels, ω-conotoxin GVIA, indicating a presynaptic requirement for N-type calcium channels in the regulation of GABAergic transmission by cannabinoids. Conversely, blocking P/Q-type channels results in increased DSI (removes a component of GABA release that is insensitive to DSI and therefore modulation of N-type calcium channels by cannabinoids is now very relevant).. Experimental description: Both mice and rats are used. "Transverse hippocampal slices (300 microns) were obtained from Sprague-Dawley rats (P16-30) or C57BL6J mice."; "CB1+/+, CB1+/- and CB1−/− mice were of both genders and varied in age from 6 weeks to 8 months"