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  • Rule: ActivityStreamsMapasEquivalentb3sb3sifpccisofacetshttp://demo.openlinksw.com/dataspacehttp://www.w3.org/2002/07/owl#ldpoplwebrel-me-authskos-transsql-vdb-data-lakeurn:ALKAdatareducedurn:analytics:acqof:ruleurn:clothing:rule:qaurn:det:rdf:labelurn:inference:oplfaq:ruleurn:inference:product:feature:inverse:ruleurn:ingleng:inf:demo:inf:ruleurn:kbpedia:actor:subclass:test:rulesurn:kbpedia:comedian:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:mime-artist:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:philosopher:owl:equivalent:class:subproperty:inference:rulesurn:kbpedia:stage-actor:owl:equivalent:class:subproperty:inference:rulesurn:kgdemo:1:ifp:ruleurn:kgdemo:1:ifp:rule2urn:lava:demo:ruleurn:owl:equivalent:class:inference:rulesurn:rdfs:subclass:subproperty:inference:rulesurn:rdfs:type:wikidata:ruleurn:recon:data:ifpurn:recon:data:ifp:ruleurn:recruitment:rule:built-in:ruleurn:rsm12e:translation:ruleurn:rxnorm:data:ruleurn:se:demo:inference:ruleurn:test:skos:inverse:ruleurn:wireless:plans:features:builtin:inference:rule:1virtrdf-eturtle-containersvirtrdf-hashtagvirtrdf-ifpvirtrdf-labelvirtrdf-meta-entity-classvirtrdf-urlNone
    
  • Inverse Functional Properties: Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects
  • "Same As": Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects (recommended) Apply to subjects, objects and predicates (not recommended on big datasets) Apply to predicates only (special use cases only)

Rationale: CB1 localized in mitochondria (mtCB1) regulates mitochondrial respiration: using purified mitochondria from wild-type (WT) or CB1−/− brains it is shown that treatment with CB1 receptor agonists WIN (Figure 3) or THC (Figure 4a-c) reduces respiration, cAMP levels and PKA activity in neuronal mitochondria. Depolarization of CA1 postsynaptic pyramidal neurons mobilizes endocannabinoids, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission in a process known as depolarization-induced suppression of inhibition (DSI), an endocannabinoid-dependent form of short-term plasticity of inhibitory neurotransmission in the hippocampus. DSI is fully blocked by cell-permeant CB1 antagonists (AM251) but only partially blocked by cell-impermeant CB1 antagonists (hemopressin) (Figure 6A), indicating a contribution of mtCB1 activation in DSI. In addition, suppression similar to the one obtained by DSI is found only with cell-permeant agonists of CB1 (HU210) but not with cell-impermeant versions (biotinylated-HU210). Also, HU210 occludes DSI completely, whereas biotinylated-HU210 only occludes it partially, suggesting again a contribution of mtCB1 activation for DSI (Figure 6C). mtCB1 activation also results in reduced mitochondrial respiration and, additionally, direct inhibition of complex I activity using rotenone also mimics DSI, suggesting that endocannabinoid-induced DSI depends on mitochondrial respiration, which would be controlled by mtCB1 (Figure 7).. Experimental description: Female mice (2–4 months old) were used for anatomy and biochemistry. Mice 20–30 d old of both sexes were used for electrophysiology.